Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation
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چکیده
منابع مشابه
Pharmacokinetics and biodistribution of amphotericin B in rats following oral administration in a novel lipid-based formulation.
OBJECTIVES To assess the pharmacokinetics and biodistribution of amphotericin B (AmB) following oral administration in a novel mono/diglyceride-phospholipid formulation and to compare with intravenous (iv) administrations using commercial formulations. METHODS Rats were allocated into the following treatment groups: oral gavage of AmB dispersed in mono/diglyceride-phospholipid formulation at ...
متن کاملBiodistribution and tissue toxicity of amphotericin B in mice following multiple dose administration of a novel oral lipid-based formulation (iCo-009).
OBJECTIVES The purpose of this study was to assess the biodistribution and toxicity of amphotericin B (AMB) following multiple dose administration of an oral lipid-based formulation (iCo-009). METHODS BALB/c female mice were used. ICo-009 was administered twice daily for 5 days at doses of 2.5-20 mg/kg. Untreated animals, oral vehicle or intravenous Fungizone® (1 or 2 mg/kg) served as control...
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ژورنال
عنوان ژورنال: Journal of Antimicrobial Chemotherapy
سال: 2010
ISSN: 0305-7453,1460-2091
DOI: 10.1093/jac/dkp474